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KMID : 0606920110190040466
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Biomolecules & Therapeutics
2011 Volume.19 No. 4 p.466 ~ p.471
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Effects of Ascaris suum Extract and Sulfamethoxazole on Allergic Airway Inflammation
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Cho Eun-Sang
Park Bae-Keun
Son Hwa-Young
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Abstract
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Allergic asthma is complex infl ammatory airway disorder caused by genetic and environmental factors. Sulfamethoxazole, a sulfonamide, is the cause of drug rash with eosinophilia and systemic symptoms syndrome. Parasites infection also related with eosinophilia and allergic diseases. In the present study, we investigated the modulating effects of parasitic derivative and sul-famethoxazole (SMX) on allergic airway infl ammation in the ovalbumin (OVA)-induced murine asthma model. Histopathological changes, cytokine secretion, and total and allergen-specifi c IgE were investigated. BALB/c mice were treated with Ascaris suum extract or SMX for 4 weeks before sensitized and challenged to ovalbumin. Pre-treatment of Ascaris suum extract decreased allergic infl ammation in lung tissue and IL-4, total IgE, and OVA-specifi c IgE levels in bronchoalveolar lavage fl uid. However, pre-treatment of SMX did not show any effects on allergic airway infl ammation. These results indicate that parasitic infection has protective effects on allergic asthma, but the sulfamamides may not relate with allergic asthma.
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KEYWORD
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Asthma, Ascaris, suum, Sulfamethoxazole, Ovalbumin, Eosinophilia
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